产品货号：
Z18823
中文名称：
IKBKG抗体
英文名称：
Anti-IKBKG Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IKBKG Antibody |
| 指标别名 | AMCBX1;FIP 3;FIP3;Fip3p;I kappa B kinase subunit gamma;IkB kinase subunit gamma;IKBKG;IKK gamma;IKKAP1;IKKG;IP;IP1;IP2;IPD2;NEMO;NF kappa B essential modifier;NF kappa B essential modulator |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | IKBKG |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-NEMO was affinity purified from whole rabbit serum prepared by repeated immunizations with a recombinant protein of human NEMO. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Anti-NEMO is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation,salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above.This antibody detects human NEMO.Cross-reactivity with NEMO from other sources is unknown. |
| 浓度 | 1.1mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Anti-NEMO antibody was designed,produced,and validated as part of the Joy Cappel Young Investigator Award (JCYIA).Anti-NEMO antibody detects recombinant and endogenous NEMO.NEMO,the regulatory subunit of the IKK core complex,phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor.Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways.Nemo is also considered to be a mediator for TAX activation of NF-kappa-B and may be implicated in NF-kappa-B-mediated protection from cytokine toxicity.NEMO is essential for viral activation of IRF3 and involved in TLR3- and IFIH1-mediated antiviral innate response.The innate antiviral response from NEMO requires 'Lys-27'-linked polyubiquitination.Anti-NEMO is ideal for researchers interested in Immunology and Cancer research. |
| Uniprot ID | Q9Y6K9 |
| 推荐稀释比 | ELISA:1:50,000 - 1:400,000 IP:5μg WB:1:500～1:1000 |
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